Science Reviews - Biology
Milena Batalla. All-natural 5-meo-dmt sigma receptor 1 agonist and its therapeutic impact in mental and neurodegenerative diseases since mitochondrial function
Posted on: May 13, 2023, 19:20:21
Description: The sigma-1 receptor (S1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (MAM), it is considered a Epluripotent modulatorE in living systems, plays a critical role in maintaining neuronal homeostasis and acts as a dynamic pluripotent modulator in living systems. Given its specific localization at the MAM, S1R plays a major role regulating mitochondrial function, it is a therapeutic target in mental and neurodegenerative diseases including AlzheimerEs disease (AD), ParkinsonEs disease (PD). N,N Dimethyl Tryptamine DMT is the S1R endogen agonists and we review the role of all natural-5-methoxi-N,N-dimethyltryptamine (5-MeO-DMT) S1R agonist that produces a strong dissolution of the ego and influence on perception, directly with the strong modulation of synaptic and cellular plasticity. 5-MeO-DMT neuropharmacological S1R agonist is implicated in cellular bioenergetics activation, antiapoptotic and mitochondrial regulation of epigenetic landscape in neurons. S1R has been considered as a controller of cell survival and differentiation in neurons. The pharmacological benefits of all-natural 5-MeO-DMT are currently under research. Hence this review compendia results, highlighting the key molecular mechanisms of S1Rs on mitochondrial functions and epigenetic modifications involved in the health and sickness phenotype development, and describe the possible pharmacological use of all-natural 5-MeO-DMT to ErescueE patients from the ill mitochondrial functioning phenotype in sickness to beneficial long-term effects on mental health and well-being of the patient reprogramming and remodeling the epigenome, particularly its clinical therapeutic implications in mental and neurodegenerative diseases.
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