Sergey N. Arkhipov. Ion Channels and Human Disease: A Review of Recent Research Advances

Posted on: Jul 22, 2025, 10:24:22

Description: Ion channels are molecular structures located in the plasma membranes of cells as well as in certain non-cellular components of the human body, animals, and other organisms. These channels play a crucial role in numerous physiological processes across various functional systems of a healthy body, including the central and peripheral nervous systems, the heart, kidneys, lungs, gastrointestinal tract, and the immune system. Dysfunction or abnormal overexpression of ion channels in tissues and organs of these systems is often associated with a wide range of pathological conditions and diseases. Targeting these disease-related ion channels with specific pharmacological inhibitors has become a well-established and widely accepted approach in biomedical research. In some cases, treatment with ion channel inhibitors has demonstrated clinical benefit, and in many others, it is regarded as a promising strategy for therapeutic intervention in ion channel-related disorders. This mini-review provides a concise overview of recent research advances (from 2022 to 2025) focusing on the role of ion channels in disease pathogenesis, as well as the therapeutic potential of specific ion channel inhibitors for improving clinical outcomes in both experimental models and human patients.

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