Prasanta Chakraborty. Gene cluster regulators for sec. metabolites in plant and microbes: role of regulators in vesicular targeting of biosynthetic intermediates/enzymes and biosynthesis of sec.metabolites

Posted on: Oct 10, 2024, 00:48:05

Description: Abstract: Plants and microbes (e.g., bacteria, fungi) produces various types of secondary metabolites (SMs) that may be used as nutraceuticals, defense molecules, drugs/antibiotics etc. Efficient biosynthesis of these SMs depend upon the transport and accumulation of biosynthetic intermediates, enzymes and transporters in a specific compartment of cells of the organism. Signals for biosynthesis of these important SMs often comes from the related gene clusters and their regulators situated inside or outside (global) the cluster. In bacteria, cluster situated regulators (CSRs), like SARPs (Streptomyces antibiotic regulatory proteins) and other regulators regulates biosynthesis of many important drugs and antibiotics, in fungi, 40% CSRs and 60% global regulators control the SM biosynthesis, whereas in plants mainly global regulators works. In this review, how these regulators play their part in the transport and efficient biosynthesis of some important compounds in plant and microbes will be discussed.

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